PRP for Degenerative Meniscal Pathology

Reviewed by Greg Jaroszynski MD, FRCSC | Last updated May 2026

Degenerative meniscal pathology often occurs as part of a broader joint wear pattern rather than as an isolated repairable injury.

Why injections may be considered

When symptoms arise from degenerative meniscal pathology and early arthritis, the goal is often to reduce pain, calm irritation, and improve function enough to progress with strengthening and activity adjustment. In this setting, I currently consider PRP the best available injection option when injection therapy is appropriate.

What PRP can and cannot do

PRP may improve pain and function in selected patients, but it should not be presented as a reliable way to regrow a meniscus, reverse arthritis, or make a severely damaged knee normal again.

When surgery may not be the first step

Many degenerative meniscal symptoms are treated without arthroscopy, especially when arthritis is present and there is no true locked knee. A structured non-surgical program may include education, activity modification, strengthening, weight management when appropriate, and selected injection therapy.

Patient selection matters

Imaging needs to be interpreted together with the history and examination. MRI findings are common with age and do not always identify the true source of pain.

Important: Injection treatment should be matched to the diagnosis, physical examination, imaging, health history, and goals. It is usually used to reduce symptoms and improve function, not to guarantee tissue regrowth or cure a structural problem.

More injection information

For a broader explanation of injection choices, evidence limits, safety issues, and references, review the main Injection Therapy section.